Masthash

#Genetics

Steven Saus [he/him]
1 day ago

From 04 Dec: Hackers stole ancestry data of 6.9 million users, 23andMe finally confirmed - EnlargeBloomberg / Contributor Bloomberg It’s now been confirmed that an addi... https://arstechnica.com/tech-policy/2023/12/hackers-stole-ancestry-data-of-6-9-million-users-23andme-finally-confirmed/ #23andme #ancestry-data #dna-relatives #dna-test-kit #dna-testing #genetics-testing #hackers #online-privacy #policy #relative-finder #security

Seth Chagi
1 day ago

I had a nice vacation, but I am back to be posting about "The Story of Us"! On this episode we hear from @johnhawks.bsky.social on #Neanderthals, #Genetics, and even a little bit about the early days of #HomoNaledi! Tune in for this awesome one-on-one!

https://www.youtube.com/watch?v=33v41AF_dA4

Planetary Ecologist
3 days ago

Dishevelled binding antagonist of beta catenin 1 (Genetics 🧬)

Dishevelled binding antagonist of beta catenin 1 is a protein that in humans is encoded by the DACT1 gene. Dact1 was originally described in 2002 as a negative regulator of Wnt signaling by binding and destabilizing Dishevelled. More recent investigation into the molecular function of Da...

https://en.wikipedia.org/wiki/Dishevelled_binding_antagonist_of_beta_catenin_1

#DishevelledBindingAntagonistOfBetaCatenin1 #Genetics #Proteins

Snowshadow
4 days ago

Peptide PACAP’s Key Role in Alcohol Addiction
Source: Boston University

Alcohol is the most common addictive substance in the world. Every year in the U.S. excessive alcohol use costs $249 billion and causes approximately 88,000 deaths, as well as various chronic diseases and social issues.

#genetics #psychology #neuroscience #science #social #neuroscience

https://neurosciencenews.com/pacap-alcohol-addiction-25298/

Snowshadow
4 days ago

UK Biobank releases half a million whole-genome sequences for biomedical research
The release more than doubles the size of an earlier data set and will help reveal new links between DNA, health, and disease, geneticists say

#genetics #biomedical #biology #science #news #uk #research #dna #health

https://www.science.org/content/article/uk-biobank-releases-half-million-whole-genome-sequences-biomedical-research

Preston MacDougall
4 days ago

#JohnSnyder and his wife #KatherineSnyder ‘adopted’ 5 orphaned babies from #China to be abused captives for years in their Hamilton County, #Ohio #BasketOfDeplorables , killing one of them when he was 8 years old. They will now spend decades in prison. https://www.huffpost.com/entry/john-katherine-snyder-sentenced-son-death_n_656a5c26e4b07b937ff4b225

If like me, you wonder why so many grotesque crimes seem to occur in Ohio, do some research on the ‘#OhioPen and #genetics. #DeplorableGene 🧬?

"Y-chromosome results highlight a significant genetic differentiation between the North-Western and South-Eastern part of the Mediterranean, the Italian Peninsula occupying an intermediate position therein. In particular, Sicily and Southern Italy reveal a shared paternal genetic background with the Balkan Peninsula and the time estimates of main Y-chromosome lineages signal paternal genetic traces of Neolithic and post-Neolithic migration events."

Sarno S, Boattini A, Carta M, Ferri G, Alù M, et al. (2014) An Ancient Mediterranean Melting Pot: Investigating the Uniparental Genetic Structure and Population History of Sicily and Southern Italy. PLOS ONE 9(4): e96074. https://doi.org/10.1371/journal.pone.0096074 #OpenAccess #OA #Research #Article #Science #STEM #Population #Genetics #PopulationGenetics #Italy #Sicily #DNA #Paleogenetics #Europe #Anthropology #Biology #Academia @science @biology @anthropology

Figure 3. Spatial Principal Component Analysis (sPCA) based on mtDNA haplogroups frequencies.

The first two global components sPC1 (a) and sPC2 (b) are depicted. Positive values are represented by black squares; negative values are represented by white squares; the size of the square is proportional to the absolute value of sPC scores.

https://doi.org/10.1371/journal.pone.0096074.g003
alok ✔️
5 days ago

It's funny to me that we're already close to most of the things from "In the Year 2525", and we're not even at 2525!

#technology #scifi #genetics #ai #vr #climatechange #classicrock

Snowshadow
5 days ago

RNA’s Pivotal Role in Fear Memory and PTSD Treatment

“Understanding the complex world of RNA is a rapidly emerging area of neuroscience research, where we are constantly learning more about how different classes of RNA control the communication between and within brain cells,” Professor Bredy said.

#neuroscience #ptsd #rna
#genetics #psychology #science #mentalhealth #news

https://neurosciencenews.com/rna-fear-memory-25295/

@mpschramm

We have published several research articles along this line. It is one of my research projects that is purely based on my personal interest😉

Because acetaldehyde damages DNA, people (especially individual with heterozygous for this allele) shouldn't be drinking a lot. But people with homozygous for this mutation are not able to drink alcohol at all, so they never become alcoholic, which seems to be a positive effect🤔

#Alcohol #ALDH2 #Acetaldehyde #Drinking #Metabolism #Genetics

Triple IPA - 11.5% alcohol 🤔

I like this bitterness and light citrus flavor. But I feel alcohol a lot, thinking about acetaldehyde, the primary metabolite of alcohol, although my enzyme (ALDH2) that detoxifies acetaldehyde has no mutation 😉
About half of East Asian people have a mutation in this enzyme. I am looking forward to seeing our kids’ genotypes 🤔

#Alcohol #Acetaldehyde #Metabolism #Science #Genetics #AcetaldehydeDehydrogenase #ALDH2

A triple IPA, Hop’solutely, is on a Maple wooden table. Its can on the side. The beer is clear and light amber golden. The can has yellowish green hops and green leaves on the light blue background like the sky.
GrrlScientist ⧖ Ⓥ :verified:
6 days ago

How Dinosaurs May Have Influenced Human Aging | out of University of Birmingham, published by BioEssays

by @GrrlScientist

#dinosaurs🦖 #aging #cancer #evolution #genetics #ecology #SciComm🧪 https://www.forbes.com/sites/grrlscientist/2023/11/30/how-dinosaurs-may-have-influenced-human-aging/

Narayoni
6 days ago

According to this study, reduction in the activity of the INPP5D gene in microglia (immune regulating cells in the brain) leads to increased neuroinflammation, potentially contributing to the progression of Alzheimer’s disease, paving the way for targeted treatments.
#science #research #openaccess #naturecommunicationsjournal #neurology #alzheimersdisease #immunology #genetics #inpp5d
https://scitechdaily.com/scientists-have-discovered-connections-between-neuroinflammation-and-alzheimers-disease/
https://www.nature.com/articles/s41467-023-42819-w

Planetary Ecologist
1 week ago

Evo-devo gene toolkit (Genetics 🧬)

The evo-devo gene toolkit is the small subset of genes in an organism's genome whose products control the organism's embryonic development. Toolkit genes are central to the synthesis of molecular genetics, palaeontology, evolution and developmental biology in the science of evolutionary developmental biology. Many of them are ancient and highly conserved...

https://en.wikipedia.org/wiki/Evo-devo_gene_toolkit

#EvoDevoGeneToolkit #Genetics #EvolutionaryBiology

ahimsa
1 week ago

Dr. Chris Ponting talked about the DecodeME study in a recent NIH webinar titled "ME/CFS Genetics/Genomics." This is part of a series of NIH webinars about ME/CFS research.

Dr. Ponting's talk runs from 11:57 - 49:35 in this video:

https://www.youtube.com/watch?v=3Sv93qHF0WQ

@mecfs

#MEcfs #CFS #MyalgicEncephalomyelitis #Genetics #GWAS #DecodeME

Nate Gaylinn
1 week ago

A while back I asked for references about gene regulatory network models and how they relate to neural networks and others.

I'm still exploring this topic, but I wanted to share back a really cool paper I found: https://sci-hub.st/10.1111/evo.12337

This paper argues that "gene networks evolve like neural networks learn," and has some very fun examples demonstrating how to do traditional machine learning using model gene regulatory networks as a medium.

It's hardly the final word on the topic, but I'm excited to see folks actively exploring how learning theory might apply to genetics! Seems very promising.

#science #genetics #neuralnetworks #machinelearning #ml #ai #grn

Dr. Marie McNeely
1 week ago

Looking to start your week with some science and great stories? In this new podcast episode, Dr. Alexis “Lekki” Wood discusses her research examining the links between food, genetics, and health. She also gives us a glimpse into her favorite activities outside of science, the twists and turns of her career path, and some of her most meaningful successes and failures.

https://www.peoplebehindthescience.com/dr-alexis-wood/

#genetics #health #nutrition #metabolism #metabolomics #research #science #STEM #WomenInSTEM #womeninscience #podcast #podcasts #scicomm #sciencecommunication #sciencecareers

On the left side of the image, the podcast's cover art is displayed. The text reads "People Behind the Science with Dr. Marie McNeely". On the right hand side, there is a headshot photo of Dr. Alexis Wood. She is a white woman with long blonde hair and blue eyes. She is wearing a blue shirt, and she is smiling at the camera. The photo was taken outside, and there is greenery in the background.

How does the Neanderthal or Denisovan DNA you carry affect your health?

https://youtu.be/D-kIrNqAB-Q

#aDNA #ancientDNA #denisovans #genetics #neanderthals

Daniel E. Weeks
1 week ago

@markjamesadams ‘Reality is an overwhelmingly immense spiderweb of causes, with a myriad downstream consequences. Wherever you choose a node in this web to mess around with – whether it be a genetic variant or a type of political system – the resulting ripples are not going to stay neatly within the confines of any crude conception of “environment” vs. “biology”.’
#genetics #GxE #causation #GvsE #environment

Prof Prachi Srivastava
1 week ago

@slcw @GhostOnTheHalfShell

I do not know enough about evolutionary biology or genetic mutation to have a sense of the applicability to this to people born to brown-eyed ancestrally homologous families who are the single solitary person to have blue eyes in their family for at least three or four generations. Grateful for evolutionary biologists out there to explain.

#Biology #EvoBio #Evolution #Genetics #Mutation #Science

Narayoni
2 weeks ago

In this study, researchers have developed an algorithm called FLSHclust for mining publicly available genomic data and have found 188 genetic clusters associated with undiscovered and rare CRISPR systems, including one that targets RNA.
https://www.science.org/doi/10.1126/science.adi1910
#science #research #crispr #genetics
https://www.nature.com/articles/d41586-023-03697-w?utm_source=Live+Audience&utm_campaign=2ccfe95815-briefing-dy-20231124&utm_medium=email&utm_term=0_b27a691814-2ccfe95815-52006460

"The Y-chromosomal variation in South Kazakh clans indicates their common origin in 13th–14th centuries AD, in agreement with the traditional genealogy. Though genetically there were at least three ancestral lineages instead of the traditional single ancestor."

Zhabagin, M., Sabitov, Z., Tarlykov, P. et al. The medieval Mongolian roots of Y-chromosomal lineages from South Kazakhstan. BMC Genet 21 (Suppl 1), 87 (2020). https://doi.org/10.1186/s12863-020-00897-5 #OpenAccess #OA #Science #Research #Article #Human #Genetics #Medieval #Kazakh #Mongol @science

"The primary objectives of this study were to assess the paternal genetic variation in Altaian Kazakh populations and their population histories, to understand the paternal origins of Kazakhs, and to elucidate the process by which this ethnic group formed."

Dulik MC, Osipova LP, Schurr TG (2011) Y-Chromosome Variation in Altaian Kazakhs Reveals a Common Paternal Gene Pool for Kazakhs and the Influence of Mongolian Expansions. PLOS ONE 6(3): e17548. https://doi.org/10.1371/journal.pone.0017548 #OpenAccess #OA #Science #Research #Article #Kazakh #Population #Genetics #PopulationGenetics #Asia @science

Kazakh populations analyzed in this study.
Seth Chagi
2 weeks ago

For today’s episode of "The Story of Us”, lets hear from famed Paleoanthropologist Dr. John Hawks, as he describes his work on #Neanderthals, #Genetics, #Homonaledi and so much more!

https://www.youtube.com/watch?v=33v41AF_dA4

Abish Stephen
2 weeks ago

Now out! 🚨

Associations between host genetic variants and subgingival microbiota in patients with the metabolic syndrome.

https://www.mdpi.com/1422-0067/24/23/16649

#microbiome #MetabolicSyndrome #genetics

Ian Sudbery
2 weeks ago

Come work with us! I have a PhD position available to help understand which mutations in the non-coding parts of coding transcripts have functional consequences in Stem Cells.

We will using genome wide mesaurement of the effect of variation in miRNA binding sites to address when vairation causes changes in regulation and when it doesn't.

Mixed wetlab, bioinformatics and statistics project.

https://www.findaphd.com/phds/project/white-rose-bbsrc-dtp-how-can-we-identify-variants-in-untranslated-rna-that-affect-stem-cells/?p160958

#phdPosition #PhD #bioinformatics #UTR #miRNA #genetics

readbeanicecream
2 weeks ago

The world's 1st CRISPR therapy has just been approved.

U.K. regulators have approved the use of a CRISPR therapy called Casgevy to treat two inherited blood disorders.

https://www.livescience.com/health/genetics/the-worlds-1st-crispr-therapy-has-just-been-approved-heres-everything-you-need-to-know

#science #health #medicine #genetics #crispr

Atheism Actually
2 weeks ago

Nice one from the counter-creationism crew
-- 40 Failed Predictions? LOL NOPE, with Science Friends --
(at Creation Myths)
https://www.youtube.com/watch?v=ITx3lIVpNR4

#creationism #intelligentDesign #evolution #science #DNA #genetics #junkDNA #astronomy #geology

Fjord In Progress
2 weeks ago

@thebiologistisn Blue Bean, Blue Bean, tell me your blue dream, do. Your purple, your yellow, combine and turn mellow, for you to become true blue.

#plants #gardening #agriculture #genetics #science

SPQR
2 weeks ago

Research reveals that children of mothers experiencing high stress, anxiety, or depression during pregnancy may have a greater risk of mental health and behavior issues throughout childhood and adolescence. #neurobiology #physiology #BrainScience #maternity #development #pregnancy #genetics #stress https://neurosciencenews.com/maternal-stress-child-mental-health-25225/

OddOpinions5
2 weeks ago

I once heard Julius Marmur say

You can go from physics or math to biology, but not the other way around

[ pause ]

I know of only one physicist who has made a real contribution to biology

I think he might have mean't Seymour Benzer
https://www.pnas.org/doi/10.1073/pnas.2115546118

#DNA #Genetics #Science #Biology #AcademicChatter #Tenure

Simon E. Fisher
2 weeks ago

Seeking applicants for #PhD projects on #genetics & #language:

1) Deciphering roles of rare genetic variants in developmental speech/language disorders. This project studies impacts of pathogenic gene disruptions by integrating data from clinical & speech/language profiles of affected patients with lab-based analyses in human neuronal models (e.g. brain organoids).

2) Mapping language-relevant genetic effects on brain variability using normative modelling. Here, we apply normative modelling to large-scale imaging & DNA data from the general population, to uncover heterogeneous effects of language-relevant genetic variants.

3) Genetic architecture of the human language network. In this project, we employ advanced neuroimaging techniques to map neural circuits involved in language processing, characterize interindividual differences in their properties, & associate them with DNA variation in unique cohorts.

Applications due before Jan 8th 2024. More info here: https://www.mpi.nl/imprs-phd-fellowships-2024

Alan Kotok
2 weeks ago

Data from three health repositories show a simple blood test reveals inherited and acquired genetic indicators, analyzed with artificial intelligence, to detect coronary heart disease.

https://sciencebusiness.technewslit.com/?p=45420

#News #Press #Science #Business #HeartDisease #CoronaryArteryDisease #Algorithms #Diagnostics #ArtificialIntelligence #MachineLearning #Genetics #Epigenetics

Ele Willoughby, PhD
3 weeks ago

Apparently it’s #FlyDay or #DrosophilaDay in honour of the day Drosophila melanogaster, the common fruit fly or vinegar fly line w1118 (the first variant with the white eyes) was isolated, so enjoy some #drosophila #sciart! This linocut print highlights the model organism with a hand-printed ring of 5 of the different eye colour genetic mutations on lovely handmade Japanese washi paper with flecks of bark inclusions. 🧵

#linocut #printmaking #sciart #genetics #MastoArt #biology #fruitFly #fly

My linocut print highlights the Drosophila fruit fly model organism  with a hand-printed ring of 5 of the different eye colour genetic mutations on lovely handmade Japanese washi paper with flecks of bark inclusions.
Daniel E. Weeks
3 weeks ago

"certain kinds of important high-dimensional geometric features are, unfortunately, mathematically impossible to represent in the 2D Euclidean plane, no matter what method is used, leading to distorted visualizations and missed geometric, and potentially biological, insights at both local and global scales."

Wang et al. What cannot be seen correctly in 2D visualizations of single-cell ’omics data? Cell Syst. 2023 Sep 20;14(9):723–731. DOI: https://doi.org/10.1016/j.cels.2023.07.002

#genetics #tSNE #UMAP #omics

Daniel E. Weeks
3 weeks ago

"Polygenic risk scores performed poorly in population screening, individual risk prediction, and population risk stratification. Strong claims about the effect of polygenic risk scores on healthcare seem to be disproportionate to their performance."

Hingorani et al. Performance of polygenic risk scores in screening, prediction, and risk stratification: secondary analysis of data in the Polygenic Score Catalog. BMJ Medicine. 2023 Oct 1;2(1). DOI: https://doi.org/10.1136/bmjmed-2023-000554
#genetics #polygenic

Poetry News
3 weeks ago
Simon E. Fisher
3 weeks ago

We are looking for talented junior scientists to join our International Max Planck Research School for Language Sciences in Nijmegen, the Netherlands. Two fully-funded 4-year #PhD fellowships (2024-2028) are available to carry out cutting-edge research on #genetics and #development of human #language, with several innovative projects to choose from, co-supervised by leading researchers at the Max Planck Institute and our partners at the Radboud University. Projects include investigating rare #DNA variants in genes that cause developmental speech/language disorders, and neuroimaging #genomic analyses of language circuits in the brain.

Application portal opens Dec 4th 2023 and closes Jan 8th 2024. Full information and FAQ can be found here: https://www.mpi.nl/imprs-phd-fellowships-2024

Boosts much appreciated!

#MastodonScience #science #academia

@mpi_nl @maxplanckgesellschaft @Radboud_uni

Photograph of the outside of the Max Planck Institute in Nijmegen, surrounded by trees.
Narayoni
3 weeks ago

This study reveals that inhibiting a specific enzyme, USP30, in a mouse model can protect dopamine-producing neurons. This finding halts the disease’s progression and opens the door to new therapeutic possibilities for the 10 million people affected by Parkinson’s worldwide.
DOI: 10.1038/s41467-023-42876-1

#science #research #openaccess #naturecommunications #parkinsonsdisease #usp30 #genetics #neurology
https://scitechdaily.com/groundbreaking-discovery-inhibiting-key-enzyme-may-halt-parkinsons-disease-progression/

Soh Kam Yung
3 weeks ago

"In a world first, the UK medicines regulator has approved a therapy that uses CRISPR gene editing as a treatment for diseases. The decision marks another high point for a biotechnology that has regularly been lauded as revolutionary in the decade since its discovery."

https://www.nature.com/articles/d41586-023-03590-6

#Medicine #Diseases #CRISPR #Genetics

Leah Brown
3 weeks ago

#NowReading

Evolution, Bergstrom and Dugatkin (3e, 2023)

#evolutionaryBiology #genetics

Selfie of the OP with a copy of the third edition of Evolution by Carl Bergstrom and Lee Alan Dugatkin
Brittany Trang
3 weeks ago

And here's our coverage of the FDA's concerns about potential off-target edits as it considers Casgevy for US approval by Dec 8:

https://www.statnews.com/2023/10/27/fda-has-some-safety-concerns-about-crispr-based-sickle-cell-treatment-documents-show/

#crispr #health #healthcare #medicine #biotech #scd #genetics #casgevy

Brittany Trang
3 weeks ago

Today the UK approved the first CRISPR-based treatment: A gene-editing treatment for beta thalassemia and sickle cell disease

We've been reporting on CRISPR for years @STAT. Here are the answers to your questions about Casgevy:

https://www.statnews.com/2023/11/16/crispr-vertex-sickle-cell-beta-thalassemia-casgevy-approval/

#crispr #health #healthcare #medicine #biotech #scd #genetics #casgevy

Steven Saus [he/him]
3 weeks ago

From 11 Nov: Mummified baboons point to the direction of the fabled land of Punt - Enlarge / Drawing of a trade expedition to Punt during the reign of Queen Hatshepsut. Note... https://arstechnica.com/science/2023/11/mummified-baboons-point-to-the-direction-of-the-fabled-land-of-punt/ #ancient-dna #ancient-egypt #archeology #baboon #dna #egypt #egyptian-mummies #genetics #science

Flipboard Science Desk
4 weeks ago

Untangling the genetics that underlie our facial features.

@KnowableMag reports: "After turning up hundreds of genes with hard-to-predict effects, some scientists are now probing the grander developmental processes that shape face geometry."

https://flip.it/HYiEvC

#Genetics #Genes #Human #Evolution #Science

pacanukeha❎
1 month ago

"When Did Humans Arrive in the Americas? #Lice Help Answer That Head-Scratcher" | #Science| Smithsonian Magazine*"

Another interesting thing:

#Genetics
https://www.smithsonianmag.com/science-nature/lice-genetics-help-show-when-humans-migrated-to-the-americas-180983217/

For example, one milestone in louse evolution likely reveals the timing of a major development in human history and culture. DNA studies show that two types of common lice, head and body lice, diverged from each other around 190,000 years ago. Since body lice are evolutionarily adapted to living in fabrics, the divergence likely indicates that humans began to wear clothing in that era, and the pests adapted to make themselves at home. Because no clothing of that era survives, the lice are the closest thing to smoking-gun evidence.
Ko-Fan Chen 陳克帆
1 month ago

are you interested in researching the relationship between #vision and #sleep? we have a fully funded #PhD opportunity using classic #drosophila #genetics, #connectome and #scRNASeq to investigate! the student will be supervised by myself and Roberto Feuda @robertofeuda at @NeurogeneticsLeicester

please see further info here and BOOST!! #neuroscience

https://warwick.ac.uk/fac/cross_fac/mibtp/phd/understanding_the_rules_of_life/visually-driven_sleep

Nicole Rust
1 month ago

Looking for paper leads on: a genetic network w/ attractor states linked to brains

I'm fond of the approaches in this paper:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2571012/

The gist here is to model a genetic network as a dynamical system with two attractor states (in this case, it's leukemia and the states are apoptosis on-versus-off).

I'm looking for leads to papers that apply this type of approach to model genetic networks (not neural circuits) that have something a bit more to do with the brain; ideally not cancer.
(This is not my field). Huntington's? Fragile X? Anything neuron related?

Thanks in advance!

#complexity #neuroscience #genetics #systemsbiology

Nate Gaylinn
1 month ago

I'd like to learn more about computational models of gene regulatory networks. Does anybody have pointers about that?

Boosts appreciated. :boost_requested:​

To be more specific, I'm looking for something analogous to artificial neural networks. Something very simplified and easy to implement. Something that focuses on the causal / informational / computational properties of gene regulatory networks in general.

That's probably different from models of specific gene networks, or computational biology tools for studying the genes of real organisms.

#genetics #dna #science

Lukas VF Novak
1 month ago

How #Kelp Keeps a Record of Environmental Calamity https://undark.org/2023/10/31/bull-kelp-destruction/

Integrating kelp #genomics analyses and geological data to reveal ancient #earthquake impacts https://royalsocietypublishing.org/doi/10.1098/rsif.2023.0105

"On a coastal rock platform near #Rārangi, #NewZealand, the team stumbled on another pocket of odd kelp #genetics. The kelp, they found, shared the genes of a population from 300 kilometers away. Something had clearly happened here."

Photo of kelp algae on rocks
Pratik Patel
1 month ago

Some deaf children in China can hear after gene treatment

"Here’s the easy game Li Xincheng has been playing at home. Her mother says a few words. Then the six-year-old, nicknamed Yiyi, repeats what she heard. “Clouds, one by one, blossomed in the mountains,” says her mother, Qin Lixue, while covering her mouth so Yiyi can’t read her lips. “Clouds, one, one, blossomed..."

https://www.technologyreview.com/2023/10/27/1082551/gene-treatment-deaf-children-hearing-china/?utm_source=press.coop

#news #tech #genetics

skry
1 month ago

He’s at the top of his field, #plant #genetics.

"He specialises in the study of sorghum, a popular source of food in Africa.

In 2009, Mr Ejeta won the prestigious World Food Prize for developing a sorghum hybrid that is resistant to both drought and the parasitic weed Striga, which commonly invades farms in Africa.

Sorghum is the fifth-most important cereal crop globally - after maize, wheat, rice and barley.

It is also the second-most important cereal in Africa” https://journa.host/@fulelo/111299738762399483

🌈 Dr Ross Brooks
1 month ago

📢 My latest article has been published online ahead of print publication in Notes and Records: The Royal Society Journal of the History of Science.

'Mendel's Closet: Genetics, Eugenics and the Exceptions of Sex in Edwardian Britain' 🌈 🧬

https://royalsocietypublishing.org/doi/10.1098/rsnr.2023.0036

#HistSTM #HSTM #HistSci @histstm #histsex #history #histodons @histodons #sex #queer #queerhistory #lgbtq #biology #science #genetics #eugenics

B&W photograph of Gregor Mendel viewed through Progress Pride flag filter.
Drea and Team
1 month ago

Today's learning resource

Understanding the difference between #ComputationalBiology & #Bioinformatics
and what each is used for.

https://graduate.northeastern.edu/resources/computational-biology-vs-bioinformatics/

#STEM #science #education #computerScience #biology #lifelongLearning
--------------------------------
For Students/Researchers :

Have you tried the CRISPR-based map that ties every human gene to its job function?

https://news.mit.edu/2022/crispr-based-map-ties-every-human-gene-to-its-function-0609

https://gwps.wi.mit.edu/

#STEM #edtech #biology #genetics #genomics #fediscience #ScienceMastodon

Julian Oliver
1 month ago

Supposed huge leak of 23andMe user data, stolen by hacker known as 'Golem'.

I and others did warn folk that this was bound to happen one day. So much of ourselves on other people's computers. Many plausible implications, if true.

(TY @Christina for this)

https://techcrunch.com/2023/10/18/hacker-leaks-millions-more-23andme-user-records-on-cybercrime-forum/

#genetics #infosec

🇵🇱 "Results showed that the level of differentiation within Polish population is quite low, but some differences were indicated. It was confirmed that the Polish population is characterized by a high degree of homogeneity, with only slight genetic differences being observed at the regional level."

Grochowalski, Ł. et al. (2020) 'Y-Chromosome Genetic analysis of modern Polish population,' Frontiers in Genetics, 11. https://doi.org/10.3389/fgene.2020.567309. #OpenAccess #OA #Science #Research #Polish #Population #Poland #Europe #Genetics #Analysis #Biology #Anthropology @science @anthropology

Flipboard Science Desk
2 months ago

People of African ancestry are poorly represented in genetic studies. A new effort would change that.

AP reports: "Scientists are setting out to collect genetic material from 500,000 people of African ancestry to create what they believe will be the world’s largest database of genomic information from the population."

https://flip.it/BZ412K

#Science #Genetics #DNA #Health #Ancestry #Black #BlackMastodon

Æva Winterschön
2 months ago

Many people of Jewish ancestry have been extremely concerned during recent years, as an unfolding timeline occurs with striking resemblance to pre-WW2 events in the USA and Europe.

This past weekend, at a rally in #SanFrancisco being held for anti-democratic Palestinian supporters, there were chants calling for genocide against the Jewish people and extremely #antiSemitic graffiti sprayed on two banks. 😔

#IStandWithIsrael #Ashkenazi #Genetics #Ancestry #Atheist #Peace #Freedom #HumanRights

An ancestry report showing the author's genetic percentage of Ashkenazi Jewish heritage, alongside a modern map of Europe with select eastern-oriented countries highlighted to show alignment of the regions in which Ashkenazi Jewish people have formerly + currently settled. 

Additional text in the image describes context around Ashkenazi populations which emigrated from those countries to the Americas after the horrors of Wold War II and its Holocaust against the Jewish peoples.

Hey Mastodon! 👋 Here is our #introduction post: We are the Data Visualization Lab at Khoury College of Computer Sciences at Northeastern University. You can find more about our work here: https://vis.khoury.northeastern.edu/

We'd love to be connected to more folks and labs in the realms of #DataVisualization #HCI #xAI #AR #VR #VisualAnalytics #PhD #Research

Our lab has been applying visualization to domain areas like #accessibility #UAVs #Genetics #Privacy #Pedagogy #Networks #GraphTheory

Say hi!

eLife
2 months ago
a clusted of round influenza virions in red ona fuzzy blue background

https://www.wired.com/story/23andme-credential-stuffing-data-stolen/

23 and me has confirmed an attack on their data. Their product features the ability to find "DNA Relatives" Hackers guessed the weak password of a single user, then used the Feature to scrape Data from other users. They then posted a portion of this data online, claiming it contained the data of over 1-million Ashkenazi Jews & 100,000+ people of Chinese Descent. The group then started selling the data for $10 per account.

#Hackers #Privacy #Data #Security #Genetics

#Genetics firm #23andMe says user data stolen in credential stuffing attack
The initial data leak was limited, with the threat actor releasing 1 million lines of data for Ashkenazi people. However, on October 4, the threat actor offered to sell data profiles in bulk for $1-$10 per 23andMe account, depending on how many were purchased. https://www.bleepingcomputer.com/news/security/genetics-firm-23andme-says-user-data-stolen-in-credential-stuffing-attack/

23andMe User Data Stolen in Targeted Attack on Ashkenazi Jews

“The company said its systems were not breached and that attackers gathered the data by guessing the login credentials of a group of users and then scraping more people’s information from a feature known as DNA Relatives. Users opt into sharing their information through DNA Relatives for others to see.”

https://www.wired.com/story/23andme-credential-stuffing-data-stolen/

#23andMe #Ashkenazi #Jews #Compromised #Hacked #DNA #Genetics

New review: Ancient DNA is an excellent intellectual history of this fascinating discipline that skillfully combines spicy interviews with serious science study.

https://inquisitivebiologist.com/2023/10/05/book-review-ancient-dna-the-making-of-a-celebrity-science/

#Books #BookReview #Bookstodon #Bookstodon #AncientDNA #Genetics #HistoryOfScience #ScienceHistory #HistSci #Scicomm @bookstodon @royalsociety

Alan Kotok
2 months ago

The Food and Drug Administration authorized marketing of a genetic test for detecting hundreds of gene variants associated with a higher risk of developing certain cancers.

https://sciencebusiness.technewslit.com/?p=45284

#News #Press #Science #Business #Cancer #Risk #Assessment #Genetics #FDA #GeneVariants #MedicalDevice #Authorization #Clearance #DeNovo #Regulations

Boggy
2 months ago

@lowqualityfacts True fact! Humans are more closely related genetically to bananas than octopus. #truefact #genetics #banana #octapus #truefactwithboggy

Project Gutenberg
2 months ago

Thomas Hunt Morgan was born #OTD in 1866.

He was an American evolutionary biologist, geneticist, embryologist, and science author who won the Nobel Prize in Physiology or Medicine in 1933 for discoveries elucidating the role that the chromosome plays in heredity.

During his distinguished career, Morgan wrote 22 books and 370 scientific papers. As a result of his work, "Drosophila" became a major model organism in contemporary genetics. via @wikipedia

#science #genetics

This image is one of several created for the 1891 Johns Hopkins yearbook of 1891, see Shine and Hobel. 1976. Thomas Hunt Morgan.
White mutation and sex-linked inheritance. Fly images are available under PD. (from THE PHYSICAL BASIS OF HEREDITY. Thomas Hunt Morgan. Philadelphia: J.B. Lippincott Company 1919)
demï7en 🎗
2 months ago

☭🇨🇳 Hoard foreign DNA data globally, by "law"... :drake_like:
☭🇨🇳 Ban foreign access to CCP subjects' DNA... :drake_like:
☭🇨🇳 Polite suggestions of rank hypocrisy? :drake_dislike:

🔥 「Chinese law makes clear that any information collected using BGI’s machines can be accessed by the Chinese government. A national intelligence law enacted in 2017 stipulates that Chinese firms and citizens are legally bound to share proprietary information acquired in foreign countries whenever requested.

🔥 Since 2019, China has also overhauled the legal framework governing its own vast genetic resources, redefining them as a strategic national resource and tightly restricting access by foreign entities for reasons including national security. Under current Chinese law, foreign entities are banned from collecting genetic material in the country or moving such resources abroad.」

#china #CCP #privacy #humanrights #genetics
@GottaLaff

Hannu Ikonen, MD
3 months ago

Also, crossover events between Y chromosome & X resulting in novel recombinations are a fucking thing, as are Barr Bodies & deactivation of chromosomes.

Dr. Ian Malcolm (Jeff Goldblum) Expertly describes [Complex Systems] & the unpredictability of emergent complexity in systems.

How these genetic variables & hormone products interplay w/brain development, self identity, processing of cultural norms, is an example of a highly variable outcome.

#JurassicPark #Genetics #Anthropology #Identity

Unexpected link between pure mathematics and genetics discovered

https://www.news-medical.net/news/20230808/Unexpected-link-between-pure-mathematics-and-genetics-discovered.aspx

"[T]he team of researchers (from Oxford, Harvard, Cambridge, GUST, MIT, Imperial, and the Alan Turing Institute) have discovered a deep connection between the sums-of-digits function from number theory and a key quantity in genetics, the phenotype mutational robustness."

#math #nature #genetics

Erin Whalen
3 months ago

A team of scientists say they've found evidence that early human ancestors went through a "prolonged, severe bottleneck" in which ~1,280 individuals capable of reproducing were able to sustain a population for about 117,000 years.

A global population maintained by only 1280 people? That's the size of a slightly larger-than-average high school. It's mind-boggling that they managed not to die out over 117,000 years.

https://www.eurekalert.org/news-releases/999720

-----
#human #history #genetics #science

⠵⠻⠷⠕⠭
3 months ago

The US security state is collecting DNA at the border and in the penal system and plundering commercial databases like geneology services people mistakenly assume are private so maybe finding out you're 17% $RACE isn't that important when you're helping to build a eugenics panopticon

FBI Hoovering (ha) Up DNA at a Pace that Rivals China, Holds 21 Million Samplea and Counting
https://theintercept.com/2023/08/29/fbi-dna-collection-surveillance/
#surveillance #militarization #genetics #police

Irritationshintergrund🍑
3 months ago

Özti war nicht weiß.
Der Ivory-Man war eine "Lady".
https://www.cbc.ca/radio/asithappens/the-ivory-lady-spain-1.6902157

Bin ja mal gespannt, was sonst noch so für Fehlannahmen über die europäische Vergangenheit ans Licht kommen.

Wenn uns AWM die Welt erklären wollen...
#science #genetics

Leanne J
3 months ago

Interesting #research email today. A while ago I took part in a study on visual pattern recognition, and just had a follow up email inviting me to more research.

I scored 100% which apparently puts me in the top 1% of people in the test. I wonder how much of this is #genetics (my eyes and brain) and how much may be influenced by practice. I’ve always been a #designer and have worked with colour, pattern & visual elements for 28 years (including education). #GraphicDesign

For @molecologist, I wrote up the huge @EvolLetters synthesis of genetic diversity data that'll be in textbook treatments of genetic drift for years to come

The glaciers of the last ice age left their mark on the genetic diversity of species across the globe

#genetics #biodiversity #evolution

https://www.molecularecologist.com/2023/08/28/the-glaciers-of-the-last-ice-age-left-their-mark-on-the-genetic-diversity-of-species-across-the-globe/

Jane Adams
3 months ago

I finished my summer internship this week! I spent 4 months working with a team of biologists and statisticians at The Jackson Laboratory, building visualization software for their research needs. The lab I worked with focuses on analyzing genetics, the microbiome, and addiction-related traits. Here's an overview of some of the EDA tools I built for them in #Python ☺️ #genetics #biology #addiction #dataviz #computerscience #research #phd

If you're doing cool work with data vis + bio, lmk!

A background section explaining the reasons for doing mouse research to understand human disease; the importance of understanding heritability for treating addiction; and introducing the complexities of the data being analyzed (large, k-partite, high dimensional)
A summary of a project to use conditional inference trees to understand interactions between microbes in predicting certain behavioral traits
An overview of a project to create a Sankey diagram comparing clustering methods applied to differential co-expression data. Everyone has their favorite clustering method, so how do we find strong signals in gene-gene similarities? By creating tools to spot concordance across methods
Project overview for a software tool that allows users to upload stacks of distance matrices, threshold on distances and features of interest, concatenate data as edgelist, and render interactive k-partite graphs to show association or anti-association between genes, microbes, and traits

Our love of nature is highly individual and how we plan our cities and urban green spaces should take this into account, say scientists

Heredity And Early Experiences Are The Reasons People Love Nature | @GoteborgsUni & @_SLU | published in @Trends_Ecol_Evo

by @GrrlScientist via @ForbesScience / @Forbes

#nature #biophilia #genetics #experiences #greenspaces #UrbanPlanning https://www.forbes.com/sites/grrlscientist/2023/08/20/heredity-and-early-experiences-are-the-reasons-people-love-nature/

Tambets, K., Yunusbayev, B., Hudjashov, G. et al. Genes reveal traces of common recent demographic history for most of the Uralic-speaking populations. Genome Biol 19, 139 (2018). https://doi.org/10.1186/s13059-018-1522-1 #OpenAccess #OA #Article #Science #Demography #History #Language #Languages #Population #Genetics #PopulationGenetics #Genomics #Biology #Geography #Europe #Asia #Academia #Academic #Academics @science @biology

Alan Kotok
4 months ago

Regeneron Pharmaceuticals, a maker of synthetic biologic treatments, is acquiring Decibel Therapeutics, developer of gene therapies to treat hearing loss and balance disorders.

https://sciencebusiness.technewslit.com/?p=45086

#News #Press #Science #Business #Finance #Acquisition #Shareholders #Biotechnology #Neuroscience #Genetics #GeneTherapy #Biologics #HearingLoss #Balance #Cochlea #ClinicalTrial

IT News
4 months ago

The Mystery Genes That Are Keeping You Alive - Nobody knows what around a fifth of your genes actually do. It’s hoped they could hold th... - https://www.wired.com/story/unknome-proteins-human-genome/ #science/health #genetics #science

Lorry
4 months ago

Dammit, I read an #article last week that I think I found here, about a species of bird, I think, that inherited newly learned predator evasion techniques in the next generation by a change in #DNA

Does anyone know what it was? I don't think I was dreaming!

#Genetics #Genome #NaturalSelection #Nature vs #Nurture vs #GeneEditing