#Neuroscience
Gene Therapy Reverses Age-Related Hearing Loss in Mice
The efficacy of adeno-associated virus (AAV) vectors in reversing genetic hearing loss in aged animal models has been demonstrated.
#Biomedicine #GeneTherapy #ViralVector #AAV #HearingLoss #AuditoryNeuroscience #Neuroscience
https://neurosciencenews.com/gene-therapy-hearing-loss-23354/
Watch "The Learning Salon - Paul Cisek" on YouTube
#evolution #behavior #neuroscience
https://www.youtube.com/live/Sx-Hb_Ljx3o?feature=share
"Learning low-dimensional dynamics from whole-brain data improves task capture"
https://arxiv.org/abs/2305.14369
#Neuroscience #ComputationalNeuroscience #MachineLearning #Neuroimaging #NeuralODE #DynamicalSystems #Cognition
"Genuine beta bursts in human working memory: controlling for the influence of lower-frequency rhythms"
https://www.biorxiv.org/content/10.1101/2023.05.26.542448v1
#Neuroscience #Neuroimaging #EEG #BetaBursts #Oscillations #WorkingMemory
"Distinct excitability of thalamocortical neurons correlates with the presence of cerebellar afferents"
https://www.biorxiv.org/content/10.1101/2023.05.26.542536v1
#Neuroscience #Electrophysiology #Cerebellum #Thalamocortical #MovementDisorders
"After screening some 5000 papers, he estimates up to 34% of neuroscience papers published in 2020 were likely made up or plagiarized; in medicine, the figure was 24%." https://science.org/content/article/fake-scientific-papers-are-alarmingly-common #Science #Medicine #Research #NeuroScience #Academia
Scientists have developed a two-photon fluorescence microscope coupled with #AdaptiveOptics, allowing in vivo #imaging of the mouse retinal structure and function. #Neuroscience https://elifesciences.org/articles/84853?utm_source=mastodon&utm_medium=social&utm_campaign=organic
Intentional Digital Habits. 28 June. 4.00am AEST but well worth the early start. https://www.mindwithheart.org/courses/zoom-workshop-intentional-digital-habits #mindovertech #digitaldetox #mediation #Mindfulness #neuroscience #agency
Hi everyone! My name is Ellie - I'm a clinical neuroscience researcher interested in exploring complex systems, science, technology, philosophy, and culture. I'd love to connect with people with similar interests on this platform, so please give me a follow!
If you're curious about my academic work, feel free to check out the Twitter in my bio.
Great Perspective by Julia Sliwa:
Toward collective animal neuroscience
Science, 374 (6566), - DOI: 10.1126/science.abm3060
It highlights that when individuals interact #socially their brains may couple some of their activity... Kind of daunting when most of our knowledge in #neuroscience is based on animals tested individually in laboratories.
» By brain is meant, in the first instance, something more than the pink-grey jelly of the anatomist. It is, even to a scientist, the organ of imagination. «
W. Grey Walter
#neuroscience
#neurotheory
#neurotech
#philosophyofmind
#philosophyofcognitivescience
#philosophyofneuroscience
#systemsneuroscience
#mindbrain
very excited to read this paper about the "gaze positioning system" in the marmoset hippocampus from Piza in Martinez-Trujillo's group.
https://www.biorxiv.org/content/10.1101/2023.05.24.542209v2
the authors suggest that whisker movements are analogous in rodents. I like the comparative approach, but would suggest that gaze positioning might also be very important for rodents too! (this is what our group is looking at, but for hearing)
Few living #neuroscience researchers have contributed to many different fields alike. Plus his unique voice in interviews clearly separating what are current conjectural hypothesis from accepted reproduced theories.
Yet after watching `In Silico` documentary, in which participates talking openly on his role as governmental hired external project observer/evaluator, I am nothing but confused about him:
+now watching this conversation with docu director & CK!
https://www.youtube.com/live/X-67MFllh6k?feature=share
How do we see the world? Scientists from the Borst department found a new microcircuit in the OFF pathway of the visual system of fruit flies. It transforms excitatory into inhibitory signals and thus leverages a single type of signal for multiple purposes. Read more: https://www.bi.mpg.de/news/2023-05-borst?c=2333712
Image by Amy Sterling, FlyWire, Murthy and Seung Labs, Princeton University.
#wisskomm #scicomm #maxplanck #research #Science #ScienceMastodon #vision #sehen #neuroscience
Albeit what about more unconscious simple tasks like heartbeat, breathing, etc? Aren't alike complex and resources intensive? Why current #neuroscience somehow demises research on those?
IMHO even worse is reflecting how huge problem is that important tasks somehow are done sometimes more, and/or others less effortlessly; Both from the subject, and from the observers' perspective.
+whose are the limits of biological, computational, philosophical, etc. translational research?
Running throughout Middle-Age Keeps Old Adult-Born Neurons Wired
Long-term running maintains the wiring of “old” new neurons, born during early adulthood, within a network that is important for memory function during aging in mice.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neurogenesis #Neuron #BrainAging #Aging #MemoryLoss #CognitiveDecline #CognitiveDysfunction #PhysicalActivity #PhysicalExercise #Running
Running Rewires the Aging Brain: Exercise Protects Memory Function
Physical activity, particularly running, has been found to rewire aging brains, helping to preserve memory functions.
Long-term running keeps older neurons wired, potentially preventing age-related memory loss and neurodegeneration.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neurogenesis #Neuron #BrainAging #Aging #MemoryLoss #CognitiveDecline #CognitiveDysfunction #PhysicalActivity #PhysicalExercise #Running
https://neurosciencenews.com/running-neurogenesis-aging-23339/
📧 Bleiben Sie mit dem #DGNC2023 Kongressnewsletter auf dem Laufenden!
❓ Sie erhalten den Newsletter noch nicht?
➡️ Dann melden Sie sich jetzt an: https://www.dgnc-kongress.de/allgemeine-informationen/newsletter-anmeldung/
#dgnc2023 #neurosurgery #neurochirurgie #neuroscience #neurologie #neurology #science #wissenschaft #forschung
Neuralink received FDA approval for implants in human brain. Great news for patients, as these implants are way, way better than anything available. (Alas much of the news focuses on the owner of the company...)
https://www.reuters.com/science/elon-musks-neuralink-gets-us-fda-approval-human-clinical-study-brain-implants-2023-05-25/
#neuroscience
Countdown Florida trying to pass a law absolving #Neuralink of responsibility for sudden death.
Colour is nothing but “a pigment of our imaginations”.
https://www.theguardian.com/books/2023/may/08/the-big-idea-why-colour-is-in-the-eye-of-the-beholder
while people post nonsense about #chatgpt, Paralyzed Man Can Walk Again With New #Brain And Spine Implants https://nature.com/articles/s41586-023-06094-5 #neuroscience #neurorehabilitation #BCI
Amazing! A brain–spine interface allows paralyzed man to walk using his thoughts.
Nature reports on the work of Grégoire Courtine, a neuroscientist at the Swiss Federal Institute of Technology.
Virtual registration is still open for the 9th Annual #BRAINInitiative Meeting (June 12-13)! https://lnkd.in/eMcXbHv3
This year's plenary sessions are:
Nita Farahany, J.D., Ph.D., on the legal & ethical implications associated with advanced technology & AI.
Sameer Sheth, M.D., Ph.D., on
on psychiatric neuromodulation: pushing the limits of personalization.
Vanessa Ruta, Ph.D., on the neural circuitry responsible for variations in animal behaviors.
It’s book launch day 🥳
It’s pretty good. You might want to buy a copy!
⏰ Der Countdown läuft: In einem Monat startet die #DGNC2023 in #Stuttgart!
🖊️ Sie sind noch nicht angemeldet? Dann schauen Sie doch auf der Website vorbei und registrieren Sie sich noch heute!
ℹ️ Alle Infos finden Sie hier: https://lnkd.in/dDzQxz4
#dgnc2023 #neurosurgery #neurochirurgie #neuroscience #neurologie #neurology #science #wissenschaft #forschung
Walking naturally after spinal cord injury using a brain–spine interface
A spinal cord injury interrupts the communication between the brain and the region of the spinal cord that produces walking, leading to paralysis. Here, we restored this communication with a digital bridge between the brain and spinal cord that enabled an individual with chronic tetraplegia to stand and walk naturally in community settings.
#Neuroscience #Neurology #Brain #SpinalCord #SpinalCordInjury #Paralysis #BrainSpineInterface #DigitalBridge #Neurotechnology #Neurotech
Wireless Brain-Spine Interface: A Leap Towards Reversing Paralysis
Researchers have designed a wireless brain-spine interface enabling a paralyzed man to walk naturally again. The ‘digital bridge’ comprises two electronic implants — one on the brain and another on the spinal cord — that decode brain signals and stimulate the spinal cord to activate leg muscles.
Remarkably, the patient experienced significant recovery in sensory perceptions and motor skills.
#Neuroscience #Neurology #Brain #SpinalCord #SpinalCordInjury #Paralysis #BrainSpineInterface #DigitalBridge #Neurotechnology #Neurotech
Is it real or imagined? How your brain tells the difference https://www.quantamagazine.org/is-it-real-or-imagined-how-your-brain-tells-the-difference-20230524/ "virtual reality and neural implants are now being investigated for medical treatments, such as to help #blind people #see again"; #AR/#VR #BCI #neuroscience
Maybe it starts with a low-energy feeling, or maybe you’re getting a little cranky. You might have a headache or difficulty concentrating. Your brain is sending you a message: You’re hungry. Find food.
Sound familiar?
Studies in mice have pinpointed a cluster of cells called AgRP neurons near the underside of the brain that may create this unpleasant hungry, even “hangry,” feeling.
🔗 Read more: https://knowablemagazine.org/article/health-disease/2023/neurons-that-make-us-feel-hangry
✍️ Amber Dance
🎨 Marina Muun
Very nice review of somatostatin interneurons.
Rhythmically stimulating the brain with electrical currents appears to boost cognitive function for peak performance in healthy people, and also help people with dementia, according to meta-analysis of 102 published studies, included 2893 individuals.
New study today in Science Translational Medicine.
https://theconversation.com/rhythmically-stimulating-the-brain-with-electrical-currents-could-boost-cognitive-function-according-to-analysis-of-over-100-studies-206169
#News #Science #NeuroScience #TACS
New study from the Klein department finds novel mechanism regulating eating behavior: the ‘hunger hormone’ ghrelin activates specialized neurons in the amygdala, which regulate appetite and cause the pleasure of eating. Read the paper:
https://www.science.org/doi/10.1126/sciadv.adf6521
#neuroscience #amygdala #brainresearch #eatingbehavior #eatingdisorders #researchnews #maxplanckinstitute
#eating #brain #wisskomm #scicomm #wissenschaftskommunikation
Neuroscientists have made a "brain computer interface" that allows a #paralyzed man to walk again by creating a wireless "digital bridge" between #brain and #spine. #AI is used to process nerve signals, filtering the ones that matter and decoding the intent before relaying them across this wireless bridge and stimulating the appropriate leg muscles. Amazing use of #tech!
Open-source tools for behavioral video analysis: Setup, methods, and best practices. #OpenSource #Neurosciencehttps://elifesciences.org/articles/79305?utm_source=mastodon&utm_medium=social&utm_campaign=organic
A parasitic fungus infects ants and manipulates their behavior. What’s happening behind the scenes in the brains of these animals? Learn more in this week's piece about zombie ants written by Marissa Maroni.
https://pennneuroknow.com/2023/05/23/can-fungus-turn-ants-into-zombies/
@Andrew_Hardaway @kordinglab Would it be possible to investigate whether high dimensional causal statements are possible (in principle?). I am waiting for Alicia Juarrero's next book (due june this year) to see if she sees a road (out of circular causation? or in closing circular causation, which might be high dimensional causation?) Do these questions make any sense?
#neuroscience #Complex #DynamicalSystems #complexity
Development and experience-dependence of #multisensory #spatial processing https://www.cell.com/trends/cognitive-sciences/fulltext/S1364-6613(23)00102-X via @ambrafer; "refinement of multisensory spatial #integration with increasing #age is further promoted by the inclusion of higher-order knowledge"; #neuroscience
Must read for those into #multisensory processing, #learning and #development. With a focus on space perception, but one could easily expand to other cognitive domains...
https://doi.org/10.1016/j.tics.2023.04.012
@cognition @neuroscience #neuroscience
@albertcardona @Andrew_Hardaway @kordinglab
I think both are correct: steady progress and impossible to predict and simulate every c.elegans behavior,
#neuroscience #ComplexDynamicalSystems #complexity
If the brain commits more resources to important tasks, how does that work at a mechanical level? More spikes? More areas actively involved? What constraints does that imply on coding and computation? Any thoughts or good reviews about this?
Short-read genome sequencing test may help diagnose atypical Friedreich's Ataxia
Test advised for patients whose symptoms, family history are not indicative of Friedreich's Ataxia.
#Neuroscience #Brain #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Cerebellum #Ataxia #FriedreichAtaxia #HereditaryAtaxias #Ataxias #NeurogeneticDiseases #Neurogenetics
Higher Vitamin D Dose in Childhood Linked to Lower Mental Health Risk
A recent study suggests higher doses of Vitamin D3 supplementation during early childhood may reduce the risk of internalizing psychiatric symptoms in later years.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #Psychiatry #PsychiatricDiseases #NeuropsychiatricDiseases #MentalHealth #VitaminD #VitaminD3 #BrainDevelopment
https://neurosciencenews.com/mental-health-child-vitamin-d-23316/
Wow, now that's some fascienating #neuroscience: "the unique insect-specific oskar gene plays a role in long-term memory through expression in adult neural stem cells. We show that oskar is expressed and required in stem cells of the adult cricket brain for long-term memory. Further, we provide evidence that oskar’s role in long-term memory involves regulation by the transcription factor Creb"
Altered grid-like coding in #early #blind people https://www.biorxiv.org/content/10.1101/2023.05.19.541468v1 "higher parietal cortex activity during #navigation in the blind was correlated with the magnitude of 4-fold #symmetry and real-word navigation abilities"; #neuroscience
Thinking about having a separate account for #Neuroscience stuff and one for everything else. But having 2 accounts seem like a lot of work. If you have tried multiple accounts, would you recommend it?
"Like morons, they are reduced to computing nothing but a thresholded sum of their inputs."
Cristof Koch has a low opinion of artificial neurons! 🤣
@elduvelle I'd be interested in the #NeuroScience and related ones! I'm #neurodivergent :flan_laugh:
What tags are you all following?
Here are mine but I’d like to add some more, particularly science-related:
#FediTips #Hippocampus #PlaceCells #Tetrodes #NatureIsBeautiful (yes… I’m the only one using it for now) #NeuroPaper #NeuroPaperThread #Neuroscience
New blog post!
I describe recent research by Mitra et al on the mechanisms of successful TMS treatment for major depressive disorder.
This is follow-up on the newly approved SNT protocol, and introduces a possible new biomarker of MDD based on resting state fMRI.
#Neuroscience #Depression #TMS #Neuromodulation #SNTProtocol
I'd love to chat with a #vision scientist about why they think some things have a "right side up" and not others. writing is strongly orientation sensitive, but brain doesn't seem to care when recognizing and processing lots of other complex objects. seems like a weird gap in my understanding and a really basic question. #neuroscience #neuro @neuro @neuroscience
Experimentalists in neuroscience use the term "manifold" a lot nowadays, often in the context of a low-dimensional manifold.
From a statistical perspective, does the low-dimensionality just mean that the neurons are correlated with each other, reducing the number of effective degrees of freedom?
Can this 'loss' of of statistical independence among neurons in an ensemble be parcellated into the effects of (1) correlation in the extrinsic inputs and (2) intrinsic connectivity?
Public voting is open for the BRAIN Initiative Show Us Your BRAINs! Photo & Video Contest. Winners will be announced at the 9th Annual BRAIN Initiative Meeting this June. Vote here: https://braininitiative.nih.gov/contests/2023-BRAIN-Initiative:-Show-Us-Your-BRAINS!-Photo-&-Video-Contest
#studyBRAIN #neuroscience #sciart #brain
We often talk about “mood swings” or “mood-altering” experiences, and some people even call one another “moody.” But what is mood, and how does it differ from emotion? https://on.dana.org/basics-mood #MentalHealthAwarenessMonth #mentalhealth #MentalHealthAwareness #mood #brain #brainhealth #neuroscience
I think that left and right frontal brain areas have stronger functional connectivity to each other than left and right occipital areas. Can anyone point me to work on that? #neuroscience @cognition @neuroscience
This year we are holding a BrainArt Competition under the theme "The Multifaceted Brain: Adaptation and Diversity". We are now accepting submissions for the BrainArt Competition! Pleas
#NeurosciArt #BrainArt #NeuroArt
#Neuroscience #Brain
#SciArt #Art
...emotions are not just a distraction from rationality that have to be fought. On the contrary, they play a key role not just in conveying affective states to others, but in guiding rationality....
Noble D, Ellis G (2022): Biological relativity revisited: the pre-eminent role of values. Theor Biol Forum 115:45–69.
#neuroscience #ComplexDynamicalSystems
Researchers at UCLA Health and Harvard have identified 10 #pesticides that significantly damaged #neurons implicated in the development of #Parkinson’s disease, providing new clues about environmental #toxins’ role in the disease.
#Environmental #Medical #Neuroscience #sflorg
https://www.sflorg.com/2023/05/en05182301.html
Researchers at Karolinska Institutet have found further evidence for how the Epstein-Barr #virus can trigger multiple #sclerosis or drive #disease progression.
#EBV #MS #Neuroscience #Virology #sflorg
https://www.sflorg.com/2023/05/ns05172301.html
I attended this as a PhD student and it was lovely!
Junior Scientist Workshop on Theoretical Neuroscience | Janelia Research Campus https://www.janelia.org/you-janelia/conferences/junior-scientist-workshop-on-theoretical-neuroscience-3
#neuroscience
John Hughlings Jackson's idea of a weighted ordinal representation.
The brain is constantly changing–but not always in the way we’d like. Tomorrow, join AARP's Vijeth Iyengar and Albert Einstein College of Medicine bioethicist Tia Powell for ideas about how to build a more resilient brain at any stage of life. Register at https://www.crowdcast.io/c/mature-brain?utm_source=DanaFoundation #scicomm #neurosociety #brainhealth #brain #neuroscience #agingbrain
Why does your dog eat grass (and other unsavory things)?
Science Focus writes: "Although the neuroscience of dogs is a growing field of study, scientists still can’t tell the exact motivation behind this puzzling behavior."
https://www.sciencefocus.com/nature/why-do-dogs-eat-grass-and-poop/
New ink brain scan #painting in indigo and black - very dramatic
#art #inkpainting #sciart #neuroscience https://etsy.me/3MsKKdv
Next month, we will discuss #intersectionality and #inclusivity in #neuroscience. We have four brilliant panelists joining us! #WomenInSTEM 🧠
Save the date & get a link to attend virtually here: https://forms.gle/i2CxgzhXui8kFUZZ7
Really enjoyed Lars Chittka's talk on #cognition in bees! Big recommendation to go watch it!
Science: Fake scientific papers are alarmingly common https://www.science.org/content/article/fake-scientific-papers-are-alarmingly-common "up to 34% of #neuroscience papers published in 2020 were likely made up or plagiarized; in #medicine, the figure was 24%"
In a novel set of experiments with mice trained to do a sequence of movements and "change course" at the spur of the moment, Johns Hopkins #scientists report they have identified areas of the animals' #brains that interact to control the ability to perform complex, sequential movements
#Neuroscience #sflorg
https://www.sflorg.com/2023/05/ns05132301.html
"Many organisms use motion to elicit stimuli from the environment that would not otherwise arise. A bacterial example would be the way in which Escherichia coli and other bacteria use motility to assess the presence of a chemical gradient".
Really excited to receive my copies of our 🧠 book today! 🥳
‘Rethinking the Brain’ comes out 25th May.
#bookunboxing #brain #neuroscience #scicomm #authorcommunity #writerslife #nonfiction
#author
#writing #fridaynews
New layered brain ink paintings with texts from Neil Gaiman, Emily Dickinson and Hildegard of Bingen on thoughts, dreams and visions.
Find them at https://www.etsy.com/shop/artologica/
#sciart #art #inkpainting #yupo #neuroscience #DCartist #painting
Our brains do not simply sit there waiting for sensory stimulations to arrive. Instead, they are buzzing proactive systems that constantly anticipate signals from the body and from the world. These are the brains of embodied agents, elegantly designed for action in the world. By moving our eyes, heads, and limbs we seek out the sensory signals that will both test and (usually) confirm our predictions. Experience takes shape as predictions of our own sensory inputs are tested, refined, and challenged in these ways.
Clark, Andy. The Experience Machine (p. 211). Knopf Doubleday Publishing Group. Kindle Edition.
#neuroscience
Specialized neurons in some insect brains, related to highly evolved behaviors, may have developed from a multifunctional ancestor Researchers have proposed a new model for the evolution of higher brain functions and behaviors in the Hymenoptera order of insects.
#BehavioralScience #Biology #Neuroscience #sflorg
https://www.sflorg.com/2023/05/bs05082301.html
he asked a colleague who replied "Russ De Valois told me that when he was a grad student and LSD was still legal, he and his advisor Matt Alpern took it to test the effects on color vision, but once it kicked in they lost interest in doing the study.” <rimshot>
"...So maybe there’s an amplification of the difference prior to noise sources, or the noise goes down. But this might also explain the “day-glo” effect of colors appearing more saturated. So you amplify small changes but end up saturating colors that would otherwise be more tame, and have trouble telling those apart."
a friend in the field wrote to me "Ya long lasting interesting. Longer than the trip itself. Seems like it’s pulling apart weak signals. Most forms of color blindness aren’t total, they’re just that the two color receptors (R & G) have more overlap in the spectrum, so typical red-green differences are muted in the internal signal space (relative to whatever noise). ..."
... and if not color blind might mushrooms give us long lasting heightened color discrimination? hmmmm
"magic mushrooms may induce lasting effects on colorblindness" (thread!)
https://medicalxpress.com/news/2023-05-case-magic-mushrooms-color-blind-vision.html #psychedelics #mushrooms #neuroscience #drugs #color
The brain-inspired decoder for natural visual image reconstruction https://www.frontiersin.org/articles/10.3389/fnins.2023.1130606/full #neuroscience #AI
Are there neural responses that look more like a derivative of the time course of a stimulus than a reproduction (or integration) of the time course?
So the response R to a stimulus S(t) would look something like
R(t) = dS/dt
(I assume the answer is yes but if any of you know of specific data, that would be awesome.)
@kottke holy cow!!!!! #neuroscience