New: Paxlovid effectiveness now 37% (began at 88%), Molnupiravir is creating mutations, data showing covid leads to Parkinson’s disease, BA.2.86 Pirola picks up a “class 1” escape mutation, Huge breakthrough to distinguish people with vs. without long covid, “Horrific” covid situation in Beijing, and many more important items.
Paxlovid is really really bitter. It tastes terrible. But it struck me that bitter ingredients like Amaro are a staple of many cocktails, like the Negroni. So I figured, what if I make a non-alcoholic cocktail but leave out the Amaro, and have it with the Paxlovid?
Technically a Negroni is Gin but I don’t have any NA gin handy. That’ll be tonight’s experiment
Paxlovid is on an EAU for age 12+, per what my spouse recalls.
We got her and our 13y kid a script after a video appt from Carbon Health, a follow up to using them for a Covid PCR test (More accurate than a RAT)
The point of the Paxlovid was to stop the virus replication, lessen chance of the acute phase being really bad, and lessen chance of long covid.
This article is about Molnupiravir. But does anybody else remember when some people floated the idea that Omicron might have been accidentally "bred" by early Paxlovid trials in Southern Africa? Is that notion just an insane conspiracy theory? Anybody know anything solid? #CovidIsNotOver #Paxlovid #omicron #LongCOVID #COVIDisAirborne https://www.theguardian.com/world/2023/sep/25/use-of-antiviral-molnupiravir-evolution-covid-virus-mutations
So day 3 of #covid taking #Paxlovid for #COVID19 and I realize there's different color foils on the back. The dusky bronze for the morning dose, grey for evening. I realized suddenly I never saw this. My splitting headache at the time made me keep the lights low and I was too fogged to notice.
Did it matter!?
Oh, I really hope not! #aDayInTheLife
Both Paxlovid, molnupiravir lower COVID Omicron deaths, hospitalizations, studies conclude.
Two new studies describe the benefits of the antiviral drugs nirmatrelvir-ritonavir (Paxlovid) and molnupiravir in reducing SARS-CoV-2 Omicron hospitalizations and death, with one finding that the former is more effective than the latter at lowering death rates.
Paxlovid and molnupiravir are used to treat nonhospitalized COVID-19 patients at high risk for severe illness within 5 days after symptom onset.
Short version, still worth taking to prevent death
" In a real-world study of people with Covid-19, Pfizer Inc.’s antiviral Paxlovid was less effective at preventing the infection’s most serious cases than it was in initial trials.
The pill was just 37% effective at preventing hospitalization or death in high-risk patients when compared to no Covid treatment at all, according to an observational study published Thursday in JAMA Network Open. In earlier studies, it cut the risk of hospitalization or death by as much as 89%.
Paxlovid is still an important drug for Covid’s worst outcome: The new study showed it was 84% effective against death alone."
#Paxlovid makes my mouth taste weird. Over an hour after taking it, the taste is still there. I guess this is how everything tastes for the next 5 days. Gonna be hard to tell if #COVID is affecting my taste or smell. In other news I'm feeling much better. Still tired and sore, but not "can't get out of bed" bad.
Well, I went 3 years and 8 months after having a #cold or #flu late December 2019 / early January 2020. Since the outbreak probably came through LAX near where I work, it was probably early #COVID-19 and it was horrible, with carry-on symptoms lasting almost a month.
Last week, I needed to attend a tech conference in Las Vegas for work. I saw masks a total of 5 times, besides my own. I aways wore my mask, but then there was this young guy in a black baseball cap, coughing and hacking in a gift shop, sounding almost like whooping cough, not masking, not even covering his mouth. Just shopping with his female friend without a care.
/You know who you are./
Is it too much to ask that you wear a mask when you are sick and have to go out of the house? Everyone is Asia does this...
Even a KN95 mask with a good seal can't keep that kind of dose of virus out, however.
My dad enquired about getting paxlovid for he (80) and my mom (79). He was told my mom doesn’t qualify because she is “low risk”, and he was told he doesn’t qualify because he is “high risk”. At that point, I think my brain just broke because absolutely nothing makes any sense anymore. #Paxlovid #COVID
Welp, I’m retracting my previous wholehearted recommendation of #Teladoc, because when I called them today after my positive test (boo!) I got a different doctor, and was told I couldn’t get #Paxlovid because I hadn’t had a recent kidney function test.
Who the fuck is out here getting routine kidney function tests? Nobody gets their kidneys tested unless there’s a problem with them. 🤬
Anyhow, the upside I guess is that I don’t have to bother masking in the house anymore. 🙃
When I came down with #COVID 2 wks ago, my doc took me off a couple of my meds so that I could do a course of Paxlovid--Rinvoq was one of them. Even tho Rinvoq only HELPS with my AS symptoms (for me, it's about 50% effective) I was worried about putting it on hold--the thought of having to deal with the horrid symptoms of COVID aaand the full pain of AS was pretty daunting. But that's not what happened. I stopped taking Rinvoq, I started taking #Paxlovid (which is NASTY but works like a fcking +
I’m picking up Paxlovid & a cough suppressant for my husband this afternoon, no hassle whatsoever (this is after his PCP refused to prescribe anything this morning).
Just days after arriving from England they all came down with covid, cancelling our imminent trip up north to see them.
My #immunocompromised wife and I were asked how we felt about spending two entire days at the PNE. My sister already knew we were opposed, this query was simply to demonstrate to visiting family how difficult we were due to our covid concerns.
We again respectfully declined, explaining this excursion was well beyond our daily risk level. We suggested a covid safe meetup outside the fair instead.
The group of 8, who had shared covid just ten days prior, then told us that this “would be difficult”.
It was explained by my sister that “unfortunately they only had 1.5 days” to spend at a crowded, wildfire smoke filled fair for what she called “A once in a lifetime experience for the kids”.
In response, she offered us a mere hour long breakfast at 8am on Sunday morning before they all returned to the fair for another 12 hours without masks.
I turned down this awkward meetup as we would have ended up driving longer than we would have seen them, and I was quite upset at being treated like we were being difficult simply because we wanted a family only visit outdoors in an unmitigated pandemic.
I suggested lunch, dinner or evening drinks on a porch; we would meet them anywhere in the city. I received no further response.
Family members I hadn’t seen in over five years chose to exclude and ignore us for their 2 days in the city due to our “paranoid” covid conscious mentality.
They came and left. No apologies or acknowledgement of what had happened, just silence and exclusion. We both felt beyond insulted and angry.
Weeks later (days ago) the phone rings. It’s my ableist right wing father who has only called me twice this whole pandemic.
He insinuates that it was disrespectful and selfish for us to miss their city visit, he’s let down that we didn’t join them at a pricey two day event with thousands of screaming strangers.
I am told that I can make it up to them by going out to the airport tomorrow morning at 8am to “spend a couple hours and see them off”.
I point out that the only reason we missed seeing everyone is because THEY all refused to put aside a moment for a covid safe visit with us.
I then explain that sitting on a covid skytrain tube for an hour to briefly meet family at an busy international airport terminal for a 2 hour long visit is once again, a risk that far exceeds my comfort level.
Dad scoffs, laughs at me and hands off the phone. “They never do anything anymore, a bunch of lazy disrespectful idiots.”
So ultimately, we the #vulnerable, not wanting to take unwarranted risks became the issue, rather than the ever-present virus itself.
All but two of the eight (including the kids who have had covid multiple times now) contracted covid on their extended vacation from reality.
My wife and I are still covid free but this time it came at a real cost. Anger, sadness, exclusion and disrespect.
We are now the black sheep of the family. Deemed selfish for not sacrificing ourselves. This is our new #covid19bc reality. Alienated, discriminated against, sacrificed and forgotten.
Can’t help but think how all this could’ve been avoided if my family had selflessly worn #masks and taken preventative measures to ensure a safe visit rather than doubling down on lies spun by #BonnieHenry and this soulless #BCndp govt.
-FDA: updated vax “not intended for everyone”
-Whoopi Goldberg on 3rd infection
-CDC: long covid in 38+ million US adults
-CVS ends Medicaid Paxlovid
-Biden mocks masking, US ER visits at winter levels
-Large, bad Biobot correction
-How to support friends w/long covid
Link, never paywalled: https://www.patreon.com/posts/pandemic-roundup-88906343
Hat hier jemand Erfahrungen, wie die aktuelle #Paxlovid-Lage ist? 60-jährige Person hat #Covid, Hausärztin die in der Vergangenheit schon mal Paxlovid verschrieben hat ist im Urlaub, Vertretung möchte es nicht verschreiben, „unsere einzige Packung ist abgelaufen, das ist aber eh nur für Risikopatienten und das hat eh niemand da“. Wie komme ich da jetzt dran?
Private, vetted email list for mental health professionals: https://www.clinicians-exchange.org
Open LEMMY instance for all mental health workers: https://lem.clinicians-exchange.org
Healthy adults not dying, but the elderly and immune compromised are.
(Later edit: It's been pointed out that "healthy" people who get COVID even once are now at an unknown level of immune compromise going forwards.)
Sobering stats and a huge study from the VA on why healthy adults want to avoid long COVID -- and how long COVID may be more common than you think.
Paxlovid -- Not only reduces complications and death, but according to one study reduces risk of long COVID by 26% over a six month period.
On masks: "If you gave the average healthy adult in America a button they could push once per day that would miraculously save the life of a random terminal patient they don't know, I figure like 60% of people wouldn't even bother to push the button on the way out the door to work each morning."
Study: Why You Should Avoid COVID Even if You're "Healthy"
NYU Information for Practice puts out 400-500 good quality health-related research posts per week but its too much for many people, so that bot is limited to just subscribers. You can subscribe at @PsychResearchBot
@upol Hopping on this to boost that if you get covid, have no doc, and live in #NewYorkState, you can get a #Paxlovid prescription and home delivery at no cost: call 212-268-4319 or surf to https://www.nychealthandhospitals.org/services/covid-19/
Thank you https://nyc-noise.com for the info (and for being the best web site for NYC weirdo culture).
wife tested positive for covid. It's bad. Online Doc is refusing to prescribe #Paxlovid citing she's <50yrs. Said LongCovid isn't real and pretty much gaslit the entire thing as a hoax.
PCP offices are closed.
CVS w/o prescription requires labwork that we don't have handy.
The blockers in the US #healthcare are systemic.
In GA, how might we get Paxlovid? Any ideas/suggestions?
Reading suggests smell loss is still common with current variants, and more often than not, comes back in weeks to months. But it's idiosyncratic , and may never come back.
We were careful and avoided it for 3.5 years, and one unmasked indoor party.
Any advice on getting smell back that worked for others?
@paninid #paxlovidRebound is when, after taking a course of #paxlovid and feeling improved & finally testing negative, there is a rebound of symptoms & testing positive again. Can happen anywhere between 2-10 days after. For me, it was testing negative for 2 days, then the rebound for a second round of symptoms & positive tests that lasted 5 additional days (it felt like being sick twice).
Doc told me it was more common than they wished. But the med still kept my symptoms from being worse
From Dr Ruth Ann Crystal's #COVID newsletter
"If you are exposed to a person who has COVID, you should #test every 48 hours x 3 (i.e. day 1, 3, 5, 7) if you have no symptoms. If you have any symptoms, test every 48 hours at least two times (day 1, 3, 5). It is best to wear an #N95 or #KN95 mask for 10 days after exposure to protect others and to isolate if you feel sick. #Paxlovid and/or #Metformin may be appropriate for some people."
Paxlovid is a combination of two medications called nirmatrelvir and ritonavir.
#Paxlovid works best when taken as soon as possible after getting a positive #COVID-19 test and within 5 days of symptoms starting. It is important to take Paxlovid as prescribed by a healthcare professional to give it the best chance of working. In clinical trials, Paxlovid reduced the risk of severe disease by 88%. https://www.perplexity.ai/search/2a7d17f5-7c44-449b-9f18-0eb478857549
As I mentioned in my mastodon alt, whole family came down with #Covid and are currently recovering, me included.
We are all fully vaxxed, and avoided this plague for 3.5 years. But it only took one indoor, unmasked birthday party with only about a dozen people to finally catch us.
#masks work. We had traveled multiple times on airlines, and trains, and in crowded public spaces.
Glad for vax, and #paxlovid for minimizing symptoms. So far, not much worse than a bad chest cold, but that's bad enough.
Appears we are all on the mend, but you do not want this bug, and it is worth it to keep masking.
Still can't comprehend how many of the world's governments are collectively shrugging on mitigation measures that are cheap and effective, like masks and ventilation.
From listener q re: vaccine efficacy w/ variants & not being able to get Paxlovid: Vaccines continue to protect against severe disease and hospitalizations even w/ current #variants. Evidence coming in that being vaxxed also protects against #LongCOVID. But if you’re at risk and can’t get #Paxlovid, Dr. Griffin suggests to talk to your doctor about other treatments like metformin. (Although he also points out that it’s not officially recommended by any society anywhere...)
Real world data about Paxlovid - it reduces hospitalization by 69%. The effect is greater in people who didn’t finish the primary vaccine series, while it didn’t help as much for people who finished the primary #vaccine series. (Although, #Paxlovid definitely helped people severely immunocompromised or over 70, when their last shot was more than 6 months ago.)
Und wie so oft kriegt man auf Englisch erheblich detailliertere Infos als auf Deutsch. Falls ihr das selber mal braucht: Interaktions-Checker für #Paxlovid mit allem anderen (Wirkstoffname eingeben, nicht Medikamentenname): https://www.covid19-druginteractions.org/checker
So weiß ich jetzt, dass doch nur eins meiner Medis besondere Sorgfalt bei einer Kurzzeitbehandlung braucht (und das ist unkompliziert fürs kurze Absetzen). Immerhin!
Schlimmstenfalls hab ich umsonst recherchiert, aber besser so als planlos positiv!
From a listener question: Some people are still having trouble getting #Paxlovid before traveling. Dr. Griffin says now that Paxlovid is fully licensed, doctors are able to prescribe Paxlovid “off-label” so that they have more flexibility and use their discretion. But of course, rich people are able to do that more easily than poor people. Dr. Griffin says he hopes the #COVID inequities will start to lessen.
Dr. Griffin joked #metformin (an inexpensive diabetes drug) is now considered a “poor man’s #Paxlovid,” which goes into the next paper: metformin reduced #COVID viral load (aka RNA copy number), but only by a teeny bit. The hosts were NOT impressed by the impact, and Dr. Racaniello wanted them to look at infectious virus. Dr. Griffin wryly observed that he wouldn’t be surprised if eventually, rich people got Paxlovid and poor people got the crappier metformin. 😅
Soo having diabetes qualifies you for paxlovid in BC but not asthma. For treating a respiratory illness. That makes sense. /s
COVID still kills 1 person every 4 minutes despite the global emergency being officially over
The best way to prevent Long Covid is to avoid getting Covid but if you do get Covid studies do show that vaccines and Paxlovid both reduce (but do not eliminate) the risk of Long Covid.
#Covid #LongCovid #vaccines #Paxlovid
Small study saw #COVID patients who took longer to clear viral RNA (rtPCR-measured) were more likely to experience #LongCOVID brain fog and muscle pain. Dr. Racaniello reminds us that viral RNA =/= infectious virus. And if there’s a reservoir of infectious virus still in the body, that might mean a later course of #Paxlovid should clear it. They’d love to see more studies using Paxlovid beyond the first 5 days - instead of preventing disease, it would be to prevent long COVID. 13/
This Week In Virology #TWIV podcast episode 1002 (April 29/23), Dr. Griffin, minute 2, "Still seeing thousands of people being hospitalized each day in the US because of covid, not just with covid, about 60% are 70 or over, meaning about 40% are under age 70, still seeing over a thousand deaths each week narrowly defined as due to covid . . . Hospitalizations: a common denominator is most people are either vaccinated or infected or both. Common denominator here is, they're not being offered antiviral treatment in the first week. People are just saying "I hope you do well" . . . . Story: I'm at a nursing station in one of the hospitals and one of the physicians: "I don't even understand why people are giving out this #Paxlovid. No one really gets sick from covid any more and no one dies or ends up in the hospital from covid." I looked at him and said, "If you'd like, you can walk 10 feet and look in the window of the gentleman who just got covid who is now on a non-rebreather and we're now having Goals of Care discussions cuz I don't think he's gonna survive. You could explain that to his wife, and you could even talk to the doctor who did not offer him treatment in the first week." #CovidIsNotOver
The FDA now only authorizing the bivalent #booster, no more monovalent. This means unvaccinated people will now get one bivalent dose and be considered vaccinated. (We’re assuming all of them have already had COVID, so single dose is considered a boost.)
Dr. Racaniello says he’s not getting another booster (he’s had 3 doses, one natural infection after, and is >65) since he doesn’t see a clear benefit for getting another dose. He’d just take #Paxlovid if he got #COVID again. 8/