There is a second research study showing possible autoimmune curative treatment that avoids wide spread immuno suppression in patients.
The previous one was regarding a "reverse vaccine". Are there any rheumatologists or researchers on here that can explain these findings in layperson terms?
Are they both targeting T cells?
I must admit, my least favorite game to play is what joint will hurt today?
Pregnancy and Rheumatoid Arthritis (RA)
“The pre-pregnancy gene expression signatures identified represent potential biomarkers to predict the subsequent improvement/worsening of RA during pregnancy, which has important implications for the personalized treatment of RA during pregnancy.”
#IDMastodon @jama_current #MedSky🧪#IDSky @JAMA Having an immune-mediated inflammatory disease (IMID), including #inflammatoryboweldisease #rheumatoidarthritis #psoriasis & #lupus, raises the risk of #venousthromboembolism (VTE), as does #SARSCoV2 infection. The incidence of VTE within 6 month of #COVID19 diagnosis among individuals with an IMID was 2.64 per 100,000 person-days vs 2.18 per 100,000 person-days among matched individuals without IMID.
Notably, certain disease risks exhibited a positive association with the severity of #COVID19 such as #alopeciatotalis, #psoriasis, #vitiligo, #vasculitis, #crohndisease #ulcerativecolitis, #rheumatoidarthritis, adult-onset Still disease, #sjogrensyndrome #ankylosingspondylitis, #sarcoidosis ,#Myocardioinfarction ,#stroke, #congestiveheartfailure .Av ages (354,527 - 52.2 yo, 50.5% 👩🦳 ,6,134,940 controls 52.1 yo, 50.1% 👩🦳.The average follow-up time for #COVID19 & control groups were 120 & 121 days
I'm not the best at #introduction (s) but here goes nothin :002blush:
hoi, I'm mana, also known as momo. I'm an FC leader in #ffxiv and I play on Primal DC. I'm shy, but one of those people who won't shut up once you get to know me. I have a tendency to be introspective/keep to myself when I'm really depressed. I have #cptsd and am #neurodivergent. Also, I'm disabled from #rheumatoidarthritis and #ehlersdanlossyndrome and #fibromyalgia. Most days are good days, but the bad ones are pretty bad :blobcat_notlikethiscry:
wow what a way to open :blobcat_nervous:
umm...I really like indie games, esp. horror ones like #Ib, #MadFather, #TheWitchsHouse, #yumenikki...stuff like that. I'm a big fan of #worldofhorror and #JunjiIto, and I've read most of #KojiSuzuki's works.
I enjoy #lightnovels and am currently reading #urasekaipicnic. I also really enjoyed #kamisamanomemochou. I like #anime but I don't really watch it all that often these days, but there's still plenty on my to-watch list :ahrispin:
I also like #visualnovels but rarely am in the mood to play them lately. some of my favorites have been the #higurashinonakukoroni series and #higanbananosakuyoruni. I also really like anything by #MAGES or #5pb / #nitroplus. #chaoshead and #steins;gate are favorites.
As far as regular video games go, I like #jrpgs, #farmingsims, #touhou & #danmaku games. I have played almost every #neptunia game :blobfoxlaughsweat: and my comfort game is #stardewvalley
I like modding/coding games so I've been learning #blender and #json to facilitate that. idk what else to say butt hi everyone, thanks for reading this if you did! let's be friends?:sbahri_question:
Not sure if it's related to the fact that I've been a lot more active (hiking up actual mountains, moving firewood for 1.5 hours, that sort of thing) or if it's the weather or if this #autoimmune disorder (probably #RheumatoidArthritis but possibly #PsoriaticArthritis the symptoms and treatments are almost identical) just is doing it's fucked up misery bullshit, but I'm in so much pain I honestly want to cry a lot of the time.
A #CharitéBerlin study now reveals: when taken in low doses, blood pressure does not increase even after a two-year treatment. Moreover, the weight gain often negatively associated with this medication is moderate, at around one kilogram (~2.2 pounds).
Every day I can accomplish some physical chores I feel good. #rheumatoidarthritis
I put pictures of my gradually healing knuckle replacement surgery up on Instagram for all y'all weirdos who like that sort of thing.
It’s a little bit empowering to find some techniques that make #methotrexate side effects more tolerable. One of the worst parts about autoimmune disease is how much is not in my control.
Taking it at night; not moving much (computer work doesn’t seem to make it much worse!); remembering the anti-nausea med.
This is my second time making an #introduction post on Mastodon.
I'm basically a geeky disabled #trans woman (she/her).
Most importantly, I love cats and have 4 of them.
Flare up. Thought I could walk it off. Got 7000 steps in, but getting worse. Took all the meds. Baked a chocolate cake and ate a big piece, because, eff it, I haven’t had any in months. Starting over tomorrow. #rheumatoidarthritis
'Zhang et al. provide crucial insights into the mechanisms driving the transition from the onset of autoimmunity to joint destruction in rheumatoid arthritis. The findings emphasize the central role of myeloid monocytes that overexpress both RANK and TLR2, and the sialylation of TLR2 in driving the fusion of monocytes and consequent resorption of bone.'
• A 24-year-old woman fled her home state of #Wisconsin to get an #abortion in #Chicago, only to find out that, upon her return, the abortion may not have worked. Before Roe’s overturning, the doctor could have immediately helped her but now, with abortion banned in WI the woman had to wait, bleeding and at risk of going into deadly #sepsis.
• Ohio, 2 women couldn’t get treatment for #cancer while pregnant.
🇬🇧 'Rheumatoid factor (RF) is seen in about half of patients w/ Sjogren's, such as erosions on xray/ MRI. RF is not specific to RA. However, there are other things that support an RA diagnosis. Important to know bc many RA drugs like TNF inhibitors are not effective for Sjogren's'.
#Sjögrens #RheumatoidArthritis #RA #RF #RheumatoidFactor #Rheumatology #rheumatologist #Neurology #neurologyst #Autoimmune #Health
There's something incredibly appealing-sounding about ice baths when it's hot and you have #RheumatoidArthritis
I got this stone paper journal at a yard sale. Sketched a plein air watercolor landscape on the blank, front page. I think I'll use the lined section for daily arthritis tracking and put a sketch on each page. That will get two things done. Tracking and a daily sketch.
I'll post the work here each day.
Won't be super intimate like a therapy journal. Looking forward to this! I'll start later today. Might break out the alcohol inks for a first try.
Update: still having my RA flare, although it seems to be moving around to different parts of my body now rather than Everything Everywhere All At Once (a fantastic movie but I don't want to be living it in my joints), so I'm cautiously optimistic that means maybe I'm on the upswing?
Anyway, if I don't reply right away or post much, that's why. Yay, bodies! 🎉🎊
Rheumatoid Arthritis - an herb known to Chinese herbal medicine *MAY* halt the progress of the disease.
"A team of researchers at OU has discovered a protein complex that plays a crucial role in the development of rheumatoid arthritis. Furthermore, their findings demonstrate that celastrol, the active compound found in the Chinese medicinal herb "Thunder God Vine", effectively hinders the advancement of the disease by inhibiting this protein complex."
for the Instagram-enabled:
My new phone wallpaper is a reminder of my #priorities. A few weeks back, my podiatrist told me that the pain #rheumatoid disease damage causes in my feet is only fixable with steroid shots in the short term and surgery that will cost me #mobility...
#Galapagos #chronicpain #accessible
#Rheumatoiddisease #frigatebird #rheumatoidarthritis #motivation #perseverance #thisiswhatsixtylookslike #thisiswhatdisabledlookslike #Ecuador
I just picked up ~85 rocks, loaded them into a wheelbarrow, and picked them up again to place them on the black plastic on the garden. For me, living with #RheumatoidArthritis, this was a great workout! And now I’m going to rake flat the soil I rototilled on Thursday.
It's interesting to me that even your little pack pony gets stats and abilities. You can eventually turn them into a warpony! Animals like wolves and bears are also capturable to put in your party if you have some Rope.
Celestia Diagnostics in #Dallas is looking for volunteers for their #microclots research. Cool opportunity as it’s one of the most promising avenues in #LongCovid research, but currently really hard to access testing for (one of the things they’re hoping to fix).
Having another flare up. Any #rheumatoidarthritis folks on here? I may have to get on a second drug other than the methotrexate. Naproxen takes care of it but don’t want to take that every day. I feel like my body has let me down. Again. This all started during the rains and then after eating sugar. Gave up the latter.😓
Back on methotrexate starting today. Last time I was on it I was totally convinced the side effects would be unbearable. I mean, I'm taking a (very low dose of a) chemotherapy drug and that feels really serious.
In hindsight, I'm pretty sure my anxiety about possibly feeling crappy was more of the issue than my actual feeling crappy. So, different attitude (we'll see what happens!) might give me a different experience?
Had my infusion today and I always say I don't need the Zyrtec & Tylenol bc it doesn't really cause me any symptoms. Well, today I'm having symptoms. UGH. (Feels like I've got a fever (haven't checked) and a cold which is normal for the day of infusion.) I wonder if that's bc of my COVID recovery? changes in my immune system? number of months I've gotten this med? Gonna grab some tylenol!
#ChronicIllness #CovidIsNotOver #RheumatoidArthritis
Going to allow myself a moment to whine. Recently diagnosed with #rheumatoidarthritis and while I wait to get into a rheumatologist so I can hopefully try to get on something control this, it is so frustrating to be in a lot of pain and people just not understanding it. Yeah, my hands don’t look all twisted. Yeah, I don’t look as bad as that person with OA and a trigger finger. But ya know what, I’m exhausted, I feel sick, and I’m in pain, but I look good. Stop comparing me to others.
For those of you living with #ChronicPain, #autoimmune disorders like #RheumatoidArthritis, do you find a connection between your emotional well-being and your levels of pain? I’ve been doing some deep work and therapy, and I am in one of the worst flares I can remember. I’m wondering if those two things are related.
fwiw i suspect giving context to photos is like needing to explain a joke,
that said, despite a lifetime working in the visual arts, now i am seriously disabled by illness and have among other things damage to my visual cortex and much diminished hand/eye coordination.
but i like to take photos with my phone sometimes just for fun. no idea what they look like to a 'normal' brain but they all are just snips of my life here. :)
Chronically ill and/or disabled and/or autistic folks, how do you not feel like a burden to everyone around you? I’m struggling with that at the moment, especially because I have no income.
Any thoughts and advice are greatly appreciated 💚
On the second to last day of my 5 days of low-dose prednisone for #RheumatoidArthritis and its #ChronicPain and I'm already feeling so much worse. Today I feel like I'm getting the flu and I'm having trouble thinking, again. It's emotionally draining, so very very disheartening, to have my "normal" be so physically miserable.
Soon my rheumatologist will give me a new medication to try, since the two I'm on now aren't working well enough.
I'm exhausted. #NEISVoid
You just don’t know who has a chronic illness and may be struggling.
We don’t always announce it or talk about it a lot. I’m always thankful to those who do bring awareness. It’s important people speak out and educate others.
We don’t choose this for ourselves. We simply do the best we can with what we’ve been given.
Today I feel a noticeable lessening of the usual 6-8/10 pain I live with bc of #RheumatoidArthritis and #IBS. I'm at the point in one of my new meds that I might see improvement in the RA. I've also started a 2nd new med that titrates (does that mean what I think it does?) faster. My overall pain is still a 4-5 and there are places that are worse. But, noticeably better. I'm feeling a flickering of hope?
Oh. And also. I went to bed a lot earlier than I usually do. Perhaps sleep helps. :-/
I haven't found my #disability community here yet. I'm kind of pondering using different accounts in different places to compartmentalize my life a little, but that often feels wrong to me.
"Changing standards and financial instability are making disabled users of Twitter anxious they may lose a valuable tool for connection and advocacy."
This makes me so happy!
Yesterday evening, this was barely a third of the way in, now it's within striking distance.
Can you drop a few dollars and help make Marie's college experience a life-changing one, all for the better?
It's still #GivingTuesday somewhere, right?
Can we help Marie get what she needs to succeed?
mother trucker my ankles feel like I twisted them in a deep rocky hole while on a mountain hike and had to get myself home on them without crutches fuhhhhhhdge
is it the weather? why am I getting caught up in the why of the pain when I know it’s just what happens sometimes?
I've seen a few other new Mastodonians posting with a bunch of hashtags in order to find their people, which I thought was a cool idea so I figured I'd give that another whirl :ablobwobble:
For anyone already following me/not interested, happy scrolling!
#BodyLiberation #DisabilityRights #Disabled #Autism #Disability #ChronicIllness #ChronicallyIll #Spoonie #RheumatoidArthritis #PsoriaticArthritis #InflammatoryPolyarthritis #Polyarthritis #VideoGames #Tabletop #TabletopGames #LGBTQIA #SocialJustice #HumanRights #Witch #Kink #SexPositive #SexPositivity #WonnaruaCountry #HunterRegion #ND #ADHD #AuDHD #AuDHDer #Indigenous #FirstNations #Cats #Foxes #AnimalRights #Disney #BDSM #NSFW #NudePhotography #Femme #SelfPhotography #TransRights #Accessibility #PersonalityTypes #MentalIllness #MentalHealth #MentallyIll #Activism #Anxiety #Depression #GAD #MDD #Kinky #SocialActivism #Psychology #Neurodivergence #Fortnite #Atmosfear #Crocs #Leftist #Anarchism #Lefty #AntiDiet #AntiDietCulture #HAES #HealthAtEverySize #IntuitiveEating #CrazyExGirlfriend #DemiLovato #McFly #MusicalTheatre #Musicals #Hamilton #LinManuelMiranda #Wicked #NatashaLyonne #Friends #Cluedo #Clue #Yellow #Fat #WLW #Sapphic #Dyke #InflammatoryArthritis #RachelBloom #Aquarius #AquariusSun #VirgoMoon #SagittariusRising #INFJ #4w5 #BlackLivesMatter
I feel I'm forgetting important things or rather there are things I'm not quite sure how to articulate so... I'll probably be back 😆